Literature

There are several published articles in medical literature and popular press regarding the anti-addictive properties of ibogaine.

• Ibogaine, Psychotherapy, and the Treatment of Substance-Related Disorders - Barbara E. Judd, CSW
• Neurologic, Electroencephalographic and General Medical Observations in Subjects Administered Ibogaine MAPS - (Bulletin of the Multidisciplinary Association for Psychedelic Studies) - Volume 9 Number 4 Winter 1999/2000 - pp. 27-30
• Seeking ways to crack cocaine addiction - Kelly Morris, The Lancet [Volume 352, Number 9136] 17 October 1998
• The Dreaming - The Independent on Sunday
• Drug might help cure addictions - An Associated Press report. (August 29, 1993)
• Fight to develop drug addiction therapy - Karen Brimingham, Nature Medicine, April 1998
• Science and medicine: Data accrue on - The Lancet [Volume 354, Number 9193] 27 November 1999
• Ibogaine - Simon Witter
• The Truth About Rapid Opiate Detox - (October 10th, 2002)
• Root of Hope CBS - CBS

Human Research with Ibogaine

• Neurologic, Electroencephalographic and General Medical Observations in Subjects Administered Ibogaine MAPS - From the Bulletin of the Multidisciplinary Association for Psychedelic Studies
• Ibogaine: Complex Pharmacokinetics, Concerns for Safety, and Preliminary Efficacy Measures - Reprinted from Neurobiological Mechanisms of Drugs of Abuse
• Neurology Dept., Univ. of Miami School of Med., Miami, FL. - J. Pablo, C.A. Kovera and D.C. Mash
• Cytochrome P4502D6 catalyzes the O-demethylation of the psychoactive alkaloid ibogaine to 12-hydroxyibogamine. - Obach RS, Pablo J, Mash DC
• Medication development of ibogaine as a pharmacotherapy for drug dependence. - Mash DC, Kovera CA, Buck BE, Norenberg MD, Shapshak P, Hearn WL, Sanchez-Ramos J
• Noribogaine stimulates naloxone-sensitive [35S]GTPgammaS binding. - Pablo JP, Mash DC
• Pharmacological screen for activities of 12-hydroxyibogamine: a primary metabolite of the indole alkaloid ibogaine. - Staley JK, Ouyang Q, Pablo J, Hearn WL, Flynn DD, Rothman RB, Rice KC, Mash DC
• Identification and quantitation of ibogaine and an o-demethylated metabolite in brain and biological fluids using gas chromatography-mass spectrometry. - Hearn WL, Pablo J, Hime GW, Mash DC
• Properties of ibogaine and its principal metabolite (12-hydroxyibogamine) at the MK-801 binding site of the NMDA receptor complex. - Mash DC, Staley JK, Pablo JP, Holohean AM, Hackman JC, Davidoff RA
• Identification of a primary metabolite of ibogaine that targets serotonin transporters and elevates serotonin. - Mash DC, Staley JK, Baumann MH, Rothman RB, Hearn WL
• Noribogaine generalization to the ibogaine stimulus: correlation with noribogaine concentration in rat brain. - Zubaran C, Shoaib M, Stolerman IP, Pablo J, Mash DC
• Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes. - Efange SM, Mash DC, Khare AB, Ouyang Q
• Ibogaine, Psychotherapy, and the Treatment of Substance-Related Disorders - Barbara E. Judd, CSW